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Selected Publications

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Wigger, M., Tröder, S. E., and Zevnik, B. (2021) A simple and economic protocol for efficient in vitro fertilization using cryopreserved mouse sperm. PLoS One 16(10), e0259202.
Butt, L., Unnersjo-Jess, D., Hohne, M., Hahnfeldt, R., Reilly, D., Rinschen, M., Plagmann, I., Diefenhardt, P., Braehler, S., Brinkkotter, P., Brismar, H., Blom, H., Schermer, B., and Benzing, T. (2021) Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease. J Am Soc Nephrol.
Hackl, A., Zed, S., Diefenhardt, P., Binz-Lotter, J., Ehren, R., and Weber, L.T. (2021) The role of the immune system in idiopathic nephrotic syndrome. Mol Cell Pediatr, 8(1): 18.
Reusch, B., Bartram, M.P., Dafinger, C., Palacio-Escat, N., Wenzel, A., Fenton, R.A., Saez-Rodriguez, J., Schermer, B., Benzing, T., Altmuller, J., Beck, B.B., and Rinschen, M.M. (2021) MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells. J Proteomics, 252: 104424.
Butt, L., Unnersjo-Jess, D., Hohne, M., Schermer, B., Edwards, A., and Benzing, T. (2021) A mathematical estimation of the physical forces driving podocyte detachment. Kidney Int, 100(5): 1054-1062.
Kuhne, L., Volker, L.A., Hagmann, H., Hagele, H., Osterholt, T., Eichenauer, D.A., Thomas, A., Breuer, J., Gruttner, B., Gottschalk, I., Kann, M., Benzing, T., Thevis, M., Muller, A.M., and Brinkkoetter, P.T. (2021) First use of the anti-VWF nanobody caplacizumab to treat iTTP in pregnancy. Br J Haematol.
Mangold, N., Pippin, J., Unnersjoe-Jess, D., Koehler, S., Shankland, S., Brahler, S., Schermer, B., Benzing, T., Brinkkoetter, P.T., and Hagmann, H. (2021) The Atypical Cyclin-Dependent Kinase 5 (Cdk5) Guards Podocytes from Apoptosis in Glomerular Disease While Being Dispensable for Podocyte Development. Cells, 10(9).
Seufert, L., Benzing, T., Ignarski, M., and Muller, R.U. (2021) RNA-binding proteins and their role in kidney disease. Nat Rev Nephrol.
Benzing, T. and Salant, D. (2021) Insights into Glomerular Filtration and Albuminuria. N Engl J Med, 384(15): 1437-1446.
Fabretti, F., Tschernoster, N., Erger, F., Hedergott, A., Buescher, A.K., Dafinger, C., Reusch, B., Köntges, V.K., Kohl, S., Bartram, M.P., Weber, L.T., Thiele, H., Altmueller, J., Schermer, B., Beck, B.B., and Habbig, S. (2021) Expanding the spectrum of FAT1 nephropathies by novel mutations that affect Hippo signaling. Kidney International Reports. 6(5): 1368-1378.
He, B., P. Chen, S. Zambrano, D. Dabaghie, Y. Hu, K. Moller-Hackbarth, D. Unnersjo-Jess, G. G. Korkut, E. Charrin, M. Jeansson, M. Bintanel-Morcillo, A. Witasp, L. Wennberg, A. Wernerson, B. Schermer, T. Benzing, P. Ernfors, C. Betsholtz, M. Lal, R. Sandberg & J. Patrakka (2021) Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes. Nat Commun, 12, 2141.
Talyan, S., S. Filipow, M. Ignarski, M. Smieszek, H. Chen, L. Kuhne, L. Butt, H. Gobel, K. J. R. Hoyer-Allo, F. C. Koehler, J. Altmuller, P. Brinkkotter, B. Schermer, T. Benzing, M. Kann, R. U. Muller & C. Dieterich (2021) CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease. Cells, 10.
Unnersjo-Jess, D., L. Butt, M. Hohne, A. Witasp, L. Kuhne, P. F. Hoyer, J. Patrakka, P. T. Brinkkotter, A. Wernerson, B. Schermer, T. Benzing, L. Scott, H. Brismar & H. Blom (2021) A fast and simple clearing and swelling protocol for 3D in-situ imaging of the kidney across scales. Kidney Int, 99, 1010-1020.
Rogg, M., Maier, J.I., Dotzauer, R., Artelt, N., Kretz, O., Helmstadter, M., Abed, A., Sammarco, A., Sigle, A., Sellung, D., Dinse, P., Reiche, K., Yasuda-Yamahara, M., Biniossek, M.L., Walz, G., Werner, M., Endlich, N., Schilling, O., Huber, T.B., and Schell, C. (2021) SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance. J Am Soc Nephrol, 32(3): 563-579.
Maier, J.I., Rogg, M., Helmstadter, M., Sammarco, A., Walz, G., Werner, M., and Schell, C. (2021) A Novel Model for Nephrotic Syndrome Reveals Associated Dysbiosis of the Gut Microbiome and Extramedullary Hematopoiesis. Cells, 10(6).
Maier, J.I., Rogg, M., Helmstadter, M., Sammarco, A., Schilling, O., Sabass, B., Miner, J.H., Dengjel, J., Walz, G., Werner, M., Huber, T.B., and Schell, C. (2021) EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission. Cell Rep, 34(12): 108883.
Weber, L.T., Tonshoff, B., Grenda, R., Bouts, A., Topaloglu, R., Gulhan, B., Printza, N., Awan, A., Battelino, N., Ehren, R., Hoyer, P.F., Novljan, G., Marks, S.D., Oh, J., Prytula, A., Seeman, T., Sweeney, C., Dello Strologo, L., and Pape, L. (2021) Clinical practice recommendations for recurrence of focal and segmental glomerulosclerosis/steroid-resistant nephrotic syndrome. Pediatr Transplant, 25(3): e13955.
Schreuder, M.F., Ehren, R., and Weber, L.T. (2021) Inadequate Dosage of Mycophenolate Mofetil Is Likely to Yield Substandard Trial Results and Substandard Patient Care. JAMA Pediatr, 175(8): 869-870.
Ehren, R. and Weber, L.T. (2021) Im Falle des Einsatzes eines Calcineurininhibitorsbei komplizierten Verläufen des nephrotischen Syndroms im Kindesalter. Kinder- und Jugendmedizin, 21(01): 27-35.
Ehren, R., Benz, M.R., Brinkkotter, P.T., Dotsch, J., Eberl, W.R., Gellermann, J., Hoyer, P.F., Jordans, I., Kamrath, C., Kemper, M.J., Latta, K., Muller, D., Oh, J., Tonshoff, B., Weber, S., Weber, L.T., and German Society for Pediatric, N. (2021) Pediatric idiopathic steroid-sensitive nephrotic syndrome: diagnosis and therapy -short version of the updated German best practice guideline (S2e) - AWMF register no. 166-001, 6/2020. Pediatr Nephrol, 36(10): 2971-2985.
Ehren, R., Benz, M.R., Brinkkotter, P.T., Dotsch, J., Eberl, W.R., Gellermann, J., Hoyer, P.F., Jordans, I., Kamrath, C., Kemper, M.J., Latta, K., Muller, D., Oh, J., Tonshoff, B., Weber, S., Weber, L.T., and German Society for Pediatric, N. (2021) Commentary on "Pediatric Idiopathic Steroid-sensitive Nephrotic Syndrome Diagnosis and Therapy - Short version of the updated German Best Practice Guideline (S2e)". Pediatr Nephrol, 36(10): 2961-2966.
Meyer, D.H. and Schumacher, B. (2021) BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy. Aging Cell, 20(3): e13320.
Rieckher, M., Garinis, G.A., and Schumacher, B. (2021) Molecular pathology of rare progeroid diseases. Trends Mol Med, 27(9): 907-922.
Schumacher, B., Pothof, J., Vijg, J., and Hoeijmakers, J.H.J. (2021) The central role of DNA damage in the ageing process. Nature, 592(7856): 695-703.

2020

Benzing, T. (2020) Molecular Design of the Kidney Filtration Barrier. Trans Am Clin Climatol Assoc, 131: 125-139.
Dafinger, C., A. M. Mandel, A. Braun, H. Gobel, K. Burgmaier, L. Massella, A. Mastrangelo, J. Dotsch, T. Benzing, T. Weimbs, B. Schermer & M. C. Liebau (2020) The carboxy-terminus of the human ARPKD protein fibrocystin can control STAT3 signalling by regulating SRC-activation. J Cell Mol Med, 24, 14633-14638.
Matin, M., Morgelin, M., Stetefeld, J., Schermer, B., Brinkkoetter, P.T., Benzing, T., Koch, M., and Hagmann, H. (2020) Affinity-Enhanced Multimeric VEGF (Vascular Endothelial Growth Factor) and PlGF (Placental Growth Factor) Variants for Specific Adsorption of sFlt-1 to Restore Angiogenic Balance in Preeclampsia. Hypertension, 76(4): 1176-1184.
Butt, L., Unnersjö-Jess, D., Höhne, M., Edwards, A., Binz-Lotter, J., Reilly, D., Hahnfeldt, R., Ziegler, V., Fremter, K., Rinschen, M.M., Helmstädter, M., Ebert, L.K., Castrop, H., Hackl, M.J., Walz, G., Brinkkoetter, P.T., Liebau, M.C., Tory, K., Hoyer, P.F., Beck, B.B., Brismar, H., Blom, H., Schermer, B., and Benzing, T. (2020) A molecular mechanism explaining albuminuria in kidney disease. Nature Metabolism, 2: 461–474
Binz-Lotter, J., Jungst, C., Rinschen, M.M., Koehler, S., Zentis, P., Schauss, A., Schermer, B., Benzing, T., and Hackl, M.J. (2020) Injured Podocytes Are Sensitized to Angiotensin II-Induced Calcium Signaling. J Am Soc Nephrol, 31(3): 532-542.
Koehler, S., Kuczkowski, A., Kuehne, L., Jungst, C., Hoehne, M., Grahammer, F., Eddy, S., Kretzler, M., Beck, B.B., Hohfeld, J., Schermer, B., Benzing, T., Brinkkoetter, P.T., and Rinschen, M.M. (2020) Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis. J Am Soc Nephrol, 31(3): 544-559.
Muller, R.U. and Schermer, B. (2020) Hippo signaling-a central player in cystic kidney disease? Pediatr Nephrol, 35(7): 1143-1152.
Erger, F., Norling, D., Borchert, D., Leenen, E., Habbig, S., Wiesener, M.S., Bartram, M.P., Wenzel, A., Becker, C., Toliat, M.R., Nurnberg, P., Beck, B.B., and Altmuller, J. (2020) cfNOMe - A single assay for comprehensive epigenetic analyses of cell-free DNA. Genome Med, 12(1): 54.
Yigit, G., Saida, K., DeMarzo, D., Miyake, N., Fujita, A., Yang Tan, T., White, S.M., Wadley, A., Toliat, M.R., Motameny, S., Franitza, M., Stutterd, C.A., Chong, P.F., Kira, R., Sengoku, T., Ogata, K., Guillen Sacoto, M.J., Fresen, C., Beck, B.B., Nurnberg, P., Dieterich, C., Wollnik, B., Matsumoto, N., and Altmuller, J. (2020) The recurrent postzygotic pathogenic variant p.Glu47Lys in RHOA causes a novel recognizable neuroectodermal phenotype. Hum Mutat, 41(3): 591-599.
Chatzidoukaki, O., Goulielmaki, E., Schumacher, B., and Garinis, G.A. (2020) DNA Damage Response and Metabolic Reprogramming in Health and Disease. Trends Genet, 36(10): 777-791.
Lopes, A.F.C., Bozek, K., Herholz, M., Trifunovic, A., Rieckher, M., and Schumacher, B. (2020) A C. elegans model for neurodegeneration in Cockayne syndrome. Nucleic Acids Res, 48(19): 10973-10985.
Wang, S., Meyer, D.H., and Schumacher, B. (2020) H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Nat Struct Mol Biol, 27(12): 1165-1177.

2019

Wostmann, F., Muller, R.U., Gobel, H., Benzing, T., Becker, J.U., and Bartram, M.P. (2019) Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome. BMC Nephrol, 20(1): 326.
Volker, L.A., Ehren, R., Grundmann, F., Benzing, T., Weber, L.T., and Brinkkotter, P.T. (2019) A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany. Nephrol Dial Transplant, 34(12): 1983-1986.
Volker, L.A., Burkert, K., Scholten, N., Grundmann, F., Kurschat, C., Benzing, T., Hampl, J., Becker, J.U., and Muller, R.U. (2019) A case report of recurrent membranoproliferative glomerulonephritis after kidney transplantation due to ventriculoatrial shunt infection. BMC Nephrol, 20(1): 296.
Phipps, E.A., Thadhani, R., Benzing, T., and Karumanchi, S.A. (2019) Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nat Rev Nephrol, 15(5): 275-289.
Kaiser, R.W.J., Ignarski, M., Van Nostrand, E.L., Frese, C.K., Jain, M., Cukoski, S., Heinen, H., Schaechter, M., Seufert, L., Bunte, K., Frommolt, P., Keller, P., Helm, M., Bohl, K., Hohne, M., Schermer, B., Benzing, T., Hopker, K., Dieterich, C., Yeo, G.W., Muller, R.U., and Fabretti, F. (2019) A protein-RNA interaction atlas of the ribosome biogenesis factor AATF. Sci Rep, 9(1): 11071.
Esmaillie, R., Ignarski, M., Bohl, K., Kruger, T., Ahmad, D., Seufert, L., Schermer, B., Benzing, T., Muller, R.U., and Fabretti, F. (2019) Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans. iScience, 22: 466-476.
Brinkkoetter, P.T., Bork, T., Salou, S., Liang, W., Mizi, A., Ozel, C., Koehler, S., Hagmann, H.H., Ising, C., Kuczkowski, A., Schnyder, S., Abed, A., Schermer, B., Benzing, T., Kretz, O., Puelles, V.G., Lagies, S., Schlimpert, M., Kammerer, B., Handschin, C., Schell, C., and Huber, T.B. (2019) Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Rep, 27(5): 1551-1566 e5.
Braun, F., Blomberg, L., Brodesser, S., Liebau, M.C., Schermer, B., Benzing, T., and Kurschat, C.E. (2019) Enzyme Replacement Therapy Clears Gb3 Deposits from a Podocyte Cell Culture Model of Fabry Disease but Fails to Restore Altered Cellular Signaling. Cell Physiol Biochem, 52(5): 1139-1150.
Assady, S., Benzing, T., Kretzler, M., and Skorecki, K.L. (2019) Glomerular podocytes in kidney health and disease. Lancet, 393(10174): 856-858
Schermer, B. and Benzing, T. (2019) Genome Editing with CRISPR/Cas9: First Steps Towards a new Era in Medicine? Dtsch Med Wochenschr, 144(4): 276-281.
Volker, L.A., Ehren, R., Grundmann, F., Benzing, T., Weber, L.T., and Brinkkotter, P.T. (2019) A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany. Nephrol Dial Transplant, 34(12): 1983-1986.
Vogd, J., Hackl, A., Habbig, S., Lechner, F., Akarkach, A., Weber, L.T., and Ehren, R. (2019) Discontinuation of maintenance therapy in frequently relapsing nephrotic syndrome. Clin Nephrol, 91(1): 25-31.
Schijvens, A.M., Ehren, R., Weber, L.T., and Schreuder, M.F. (2019) The quest for optimal control of relapses in children with nephrotic syndrome. Kidney Int, 95(3): 717.
Ehren, R., Brinkkötter, P., Weber, L.T., and Querfeld, U. (2019) Nephrotisches Syndrom des Kindes- und Jugendalters. Der Nephrologe, 14(3): 184-191.
Benz, M.R., Ehren, R., Kleinert, D., Muller, C., Gellermann, J., Fehrenbach, H., Schmidt, H., and Weber, L.T. (2019) Generation and Validation of a Limited Sampling Strategy to Monitor Mycophenolic Acid Exposure in Children With Nephrotic Syndrome. Ther Drug Monit, 41(6): 696-702.
Doll, M.A., Soltanmohammadi, N., and Schumacher, B. (2019) ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans. Genetics, 213(1): 173-194.
Odenthal, J. and Brinkkoetter, P.T. (2019) Drosophila melanogaster and its nephrocytes: A versatile model for glomerular research. Methods Cell Biol, 154: 217-240.
Ou, H.L., Kim, C.S., Uszkoreit, S., Wickstrom, S.A., and Schumacher, B. (2019) Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. Dev Cell, 50(2): 167-183 e8.
Bayersdorf, R. and Schumacher, B. (2019) Recent advances in understanding the mechanisms determining longevity. F1000Res, 8.
da Silva, P.F.L. and Schumacher, B. (2019) DNA damage responses in ageing. Open Biol, 9(11): 190168.
Rive, C., Reina, G., Wagle, P., Treossi, E., Palermo, V., Bianco, A., Delogu, L.G., Rieckher, M., and Schumacher, B. (2019) Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans. Small, 15(45): e1902699.

2018

Slaats, G.G., Braun, F., Hoehne, M., Frech, L.E., Blomberg, L., Benzing, T., Schermer, B., Rinschen, M.M., and Kurschat, C.E. (2018) Urine-derived cells: a promising diagnostic tool in Fabry disease patients. Sci Rep, 8(1): 11042.
Volker, L.A., Maar, B.A., Pulido Guevara, B.A., Bilkei-Gorzo, A., Zimmer, A., Bronneke, H., Dafinger, C., Bertsch, S., Wagener, J.R., Schweizer, H., Schermer, B., Benzing, T., and Hoehne, M. (2018) Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents. Genes Brain Behav: e12516.
Karaiskos, N., Rahmatollahi, M., Boltengagen, A., Liu, H., Hoehne, M., Rinschen, M., Schermer, B., Benzing, T., Rajewsky, N., Kocks, C., Kann, M., and Muller, R.U. (2018) A Single-Cell Transcriptome Atlas of the Mouse Glomerulus. J Am Soc Nephrol. 29(8):2060-2068.
Rinschen, M.M., Godel, M., Grahammer, F., Zschiedrich, S., Helmstadter, M., Kretz, O., Zarei, M., Braun, D.A., Dittrich, S., Pahmeyer, C., Schroder, P., Teetzen, C., Gee, H., Daouk, G., Pohl, M., Kuhn, E., Schermer, B., Kuttner, V., Boerries, M., Busch, H., Schiffer, M., Bergmann, C., Kruger, M., Hildebrandt, F., Dengjel, J., Benzing, T., and Huber, T.B. (2018) A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes. Cell Rep, 23(8): 2495-2508.
Tröder, S.E., Ebert, L.K., Butt, L., Assenmacher, S., Schermer, B., Zevnik, B. (2018) An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes. PLoS One, 13(5):e0196891.
Schroeter, C.B., Koehler, S., Kann, M., Schermer, B., Benzing, T., Brinkkoetter, P.T., Rinschen, M.M. (2018) Protein half-life determines expression of proteostatic networks in podocyte differentiation. FASEB J, 32(9): 4696-4713.
Hohne, M., Frese, C.K., Grahammer, F., Dafinger, C., Ciarimboli, G., Butt, L., Binz, J., Hackl, M.J., Rahmatollahi, M., Kann, M., Schneider, S., Altintas, M.M., Schermer, B., Reinheckel, T., Gobel, H., Reiser, J., Huber, T.B., Kramann, R., Seeger-Nukpezah, T., Liebau, M.C., Beck, B.B., Benzing, T., Beyer, A., and Rinschen, M.M. (2018) Single nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int, 93(6):1308-1319.
Hagmann, H., Mangold, N., Rinschen, M.M., Koenig, T., Kunzelmann, K., Schermer, B., Benzing, T., and Brinkkoetter, P.T. (2018) Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression. FASEB J, 32(1): 208-219.
Querfeld, U. and Weber, L.T. (2018) Treatment strategies for children with steroid-dependent nephrotic syndrome: in need of controlled studies. Pediatr Nephrol, 33(12): 2391.
Querfeld, U. and Weber, L.T. (2018) Mycophenolate mofetil for sustained remission in nephrotic syndrome. Pediatr Nephrol, 33(12): 2253-2265.
Hoefele, J., Beck, B.B., Weber, L.T., and Brinkkötter, P. (2018) Steroid-resistentes nephrotisches Syndrom. medizinische genetik, 30(4): 410-421.
Ehren, R., Benz, M.R., Doetsch, J., Fichtner, A., Gellermann, J., Haffner, D., Hocker, B., Hoyer, P.F., Kastner, B., Kemper, M.J., Konrad, M., Luntz, S., Querfeld, U., Sander, A., Toenshoff, B., Weber, L.T., and Gesellschaft fur Padiatrische, N. (2018) Initial treatment of steroid-sensitive idiopathic nephrotic syndrome in children with mycophenolate mofetil versus prednisone: protocol for a randomised, controlled, multicentre trial (INTENT study). BMJ Open, 8(10): e024882.
Torgovnick, A., Heger, J.M., Liaki, V., Isensee, J., Schmitt, A., Knittel, G., Riabinska, A., Beleggia, F., Laurien, L., Leeser, U., Jungst, C., Siedek, F., Vogel, W., Klumper, N., Nolte, H., Wittersheim, M., Tharun, L., Castiglione, R., Kruger, M., Schauss, A., Perner, S., Pasparakis, M., Buttner, R., Persigehl, T., Hucho, T., Herter-Sprie, G.S., Schumacher, B., and Reinhardt, H.C. (2018) The Cdkn1a(SUPER) Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Rep, 25(4): 1027-1039 e6.

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