The central project (CP1) encompasses the scientific coordination and administrative organization of the Clinical Research Unit, rotational positions for physician scientists (Gerok positions), measures for gender and family support, as well as the educational program. It is the distinct goal of this CRU to translate basic science into clinical applications in diagnostics and therapy of glomerular diseases, in particular FSGS and MCD. Therefore, it is very important to promote the interaction between scientists from the natural sciences and physician scientists. To engage young physicians into basic research we will create rotational positions. Moreover, CP1 will organize the annual meeting on glomerular biology and all measures regarding public relations.
KEY PUBLICATIONS OF THE CRU329
- Butt, L., Unnersjo-Jess, D., Hohne, M., Schermer, B., Edwards, A., and Benzing, T. (2021) A mathematical estimation of the physical forces driving podocyte detachment. Kidney Int, 100(5): 1054-1062.
- Benzing, T. and Salant, D. (2021) Insights into Glomerular Filtration and Albuminuria. N Engl J Med, 384(15): 1437-1446.
- Schumacher, B., Pothof, J., Vijg, J., and Hoeijmakers, J.H.J. (2021) The central role of DNA damage in the ageing process. Nature, 592(7856): 695-703.
- Butt, L., Unnersjö-Jess, D., Höhne, M., Edwards, A., Binz-Lotter, J., Reilly, D., Hahnfeldt, R., Ziegler, V., Fremter, K., Rinschen, M.M., Helmstädter, M., Ebert, L.K., Castrop, H., Hackl, M.J., Walz, G., Brinkkoetter, P.T., Liebau, M.C., Tory, K., Hoyer, P.F., Beck, B.B., Brismar, H., Blom, H., Schermer, B., and Benzing, T. (2020) A molecular mechanism explaining albuminuria in kidney disease. Nature Metabolism, 2: 461–474
- Binz-Lotter, J., Jungst, C., Rinschen, M.M., Koehler, S., Zentis, P., Schauss, A., Schermer, B., Benzing, T., and Hackl, M.J. (2020) Injured Podocytes Are Sensitized to Angiotensin II-Induced Calcium Signaling. J Am Soc Nephrol, 31(3): 532-542.
- Brinkkoetter, P.T., Bork, T., Salou, S., Liang, W., Mizi, A., Ozel, C., Koehler, S., Hagmann, H.H., Ising, C., Kuczkowski, A., Schnyder, S., Abed, A., Schermer, B., Benzing, T., Kretz, O., Puelles, V.G., Lagies, S., Schlimpert, M., Kammerer, B., Handschin, C., Schell, C., and Huber, T.B. (2019) Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics. Cell Rep, 27(5): 1551-1566 e5.
- Assady, S., Benzing, T., Kretzler, M., and Skorecki, K.L. (2019) Glomerular podocytes in kidney health and disease. Lancet, 393(10174): 856-858
- Karaiskos, N., Rahmatollahi, M., Boltengagen, A., Liu, H., Hoehne, M., Rinschen, M., Schermer, B., Benzing, T., Rajewsky, N., Kocks, C., Kann, M., and Muller, R.U. (2018) A Single-Cell Transcriptome Atlas of the Mouse Glomerulus. J Am Soc Nephrol. 29(8):2060-2068.
